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innate immunity to pulmonary infection, no. 279
Novartis Foundation (Autor)
·
wiley
· Libro Físico
innate immunity to pulmonary infection, no. 279 - novartis foundation
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Origen: Reino Unido
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Reseña del libro "innate immunity to pulmonary infection, no. 279"
the global epidemic of tuberculosis is one of the better known and more widely studied lung infections. many other microorganisms affect both adults and children: pyogenic bacteria such as streptococcus pneumoniae and haemophilus influenzae, viruses such as influenza and respiratory syncytial virus and fungal agents such as pneumocystis carinii and cryptococcus (nosocomial, 2° immunodeficiency and primary). in addition, there is an increasing incidence of asthma, associated with urbanization. occupational lung disease is still prevalent in many countries, such as silico-anthracosis and asbestosis in miners. innate immunity is now seen as a major topic in immunology and as key to the pathogenesis of and vaccination strategies for infectious diseases. it is time to apply the knowledge derived concerning cellular and molecular mechanisms of innate resistance to infection to human diseases, and the book discusses ways of doing this. the lung is an important target for environmental pathogens, as well as for opportunistic infection, and could be a fertile source of cells and clinical/pathological materials to investigate disease in a genetically varied population. this book covers the roles of cells such as neutrophils, macrophages and dendritic cells and of molecular components such as toll-like receptors. it describes the genetic and environmental factors which determine the outcome of infection (latency of tuberculosis, blood stream invasion from local infection, local target tissue damage). this book draws together much new and exciting work in this area, and this timely publication stimulates the clinical application of our expanding knowledge of innate immunity in lung disease.
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