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sepsis: new insights, new therapies, novartis foundation symposium, no. 280
Novartis Foundation (Autor)
·
wiley
· Libro Físico
sepsis: new insights, new therapies, novartis foundation symposium, no. 280 - novartis foundation
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Origen: Reino Unido
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Reseña del libro "sepsis: new insights, new therapies, novartis foundation symposium, no. 280"
the number of deaths from sepsis each year rivals those occurring from myocardial infarction and exceeds the mortality rate of virtually every common cancer, yet the syndrome has received relatively little attention as a modifiable disease process. greater appreciation of the highly complex pathophysiology by which sepsis induces multiple organ failure has stimulated research into new therapeutic approaches involving immune, neural, hormonal, metabolic and bioenergetic pathways that are both affected by, and influence, the inflammatory response. depending on the phase of the septic syndrome, this could even involve stimulation of inflammatory, immune or other systems, so the timing of any intervention is critical. the book discusses the best ways to develop such interventions. with developments in bedside monitoring of these varied systems, and advances in supportive care in the intensive care unit, the ability to titrate treatment individually is becoming both an increasing reality and a necessity. nonetheless, the aggregate mortality of severe sepsis at one month remains at ca. 30% in north america and europe, and is much higher in the developing world. most therapeutic strategies to date have targeted pro-inflammatory mediators but, unfortunately, most of these strategies have not improved survival of patients when studied in large, multicentre clinical trials. this book brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.